validation of DCIS markers to predict IDC

Institution: CRUK Cambridge University
Corresponding Researcher: clare rebbeck
Email: clare.rebbeck@cruk.cam.ac.uk
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Summary

We have previously identified a small set of markers from RNAseq data of individually LCM DCIS samples, which were able to segregate DCIS patients to those with pure DCIS from those with IDC (both co-occuring or later occurring). We are using the BCNB tissue samples to validate these markers in a new cohort using RNAscope.