Epigenetic deprogramming by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers

Institution: University of York

Corresponding Researcher: Dawn Coverley

Email: dawn.coverley@york.ac.uk

Publication Link(s): https://doi.org/10.1083/jcb.202409123

Data Link(s): NA

Keyword(s): Breast cancer, CIZ1, X chromosome, RNA-protein complexes, Chromatin

Summary

This paper shows that protein fragments derived from the CIZ1 gene disperse nuclear CIZ1-RNA assemblies, exposing underly loci and changing gene expression. The interference mechanism is implicated as a driver of epigenetic instability in early-stage breast cancers.