Approved Project
How does the local microbiome in the tumour microenvironment affect immune cell activation
Keyword(s): microbiome, spatial analysis, tissue micro array
Year: 2023
Approved Project
Characterising sub-clonal diversity for improved patient stratification in therapy resistant breast cancer
Keyword(s): Triple negative breast cancer, neoadjuvant therapy, therapy resistance, metastasis, invasive lobular breast cancer
Year: 2023
Approved Project
Serial Assessment of breast cancers using Multispectral Imaging, Raman Spectroscopy and Mass Spectral Analysis - Towards Intraoperative Margin Assessment for Breast Conserving Surgery
Keyword(s): multispectral imaging; Raman spectroscopy; Mass spectrometry; intraoperative margin assessment tool
Year: 2023
Approved Project
Restoring response to immunotherapy by targeting the extracellular matrix
Keyword(s): extracellular matrix, TNBC, immune infiltration
Year: 2023
Approved Project
DUBs that regulate centrosome clustering: an Achille's heel of cancer
Keyword(s): Triple negative breast cancer; Cell-cycle; Centrosome clustering; Ubiquitin; DNA-damage; Developing new treatment strategies
Year: 2023
Approved Project
Establishing the UK-Qatar Precision Healthcare collaborative
Keyword(s): RNA, transcriptomics, functional genomics, FFPE, RNA-seq, DCIS, IDC, Qatar, Nanostring
Year: 2023
Approved Project
Bioengineering approaches to investigate cancer therapy induced senescence and accelerated ageing
Keyword(s): Breast cancer, Extracellular Matrix, ageing, 3D models,
Year: 2023
Approved Project
BACE1 in Breast Cancer
Keyword(s): Breast Cancer, BACE1,
Year: 2023
Publications
A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis
Institution: Department of Biology, University of York
Keyword(s): sodium ions, voltage-gated Na+ channels, cancer-associated fibroblasts, xenografts, metastases, Nav1.5
Summary: Solid tumours have abnormally high intracellular [Na+]. The activity of various Na+ transporting proteins including channels may underlie this Na+ accumulation. Here, we show th...
Year: 2023
