Publications
A proteolytic landscape: understanding the role of myoepithelial cells in early-stage breast cancer progression
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): -
Summary: Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Despite evidence suggesting that up to half of DCIS cases would remain stable and non-thre...
Year: 2023
Publications
ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): proteases, ADAMTS3, luminal cells, fibronectin
Summary: Proteases have long been associated with cancer progression, due to their ability to facilitate invasion upon matrix remodelling. However, proteases are not simply degraders of...
Year: 2023
Publications
Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry
Institution: University College London
Keyword(s): low-frequency variants, susceptibility, European ancestry, Asian ancestry, African ancestry, Latin American ancestry, Hispanic ancestry
Summary: BACKGROUND. Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same...
Year: 2023
Publications
Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival
Institution: Erasmus MC Cancer Institute
Keyword(s): germline mutations, CHEK2 c.1100delC, contralateral breast cancer,
Summary: BACKGROUND. Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared...
Year: 2023
Publications
Associations of a breast cancer polygenic risk score with tumor characteristics and survival
Institution: Netherlands Cancer Institute; Leiden University Medical Center
Keyword(s): -
Summary: PURPOSE. A polygenic risk score (PRS) consisting of 313 common genetic variants (PRS313) is associated with risk of breast cancer and contralateral breast cancer. This study aim...
Year: 2023
Publications
Characterization of the immune microenvironment in inflammatory breast cancer using multiplex immunofluorescence
Institution: Institute of Cancer and Genomic Sciences, University of Birmingham; Queen Elizabeth Hospital Birmingham
Keyword(s): tumour microenvironment, inflammatory breast cancer, immune cells, multiplex immunofluorescence
Summary: INTRODUCTION. Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poorly characterized immune microenvironment. METHODS. We used a five-colour multipl...
Year: 2023
Publications
Dynamic biobanking for advancing breast cancer research
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): translational research, precision medicine, electronic health records, genomics, health informatics, bioinformatics
Summary: Longitudinal patient biospecimens and data advance breast cancer research through enabling precision medicine approaches for identifying risk, early diagnosis, improved disease...
Year: 2023
Publications
Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel
Institution: Tel Aviv University
Keyword(s): polygenic risk scores, genome-wide association studies, European ancestry, Ashkenazi Jewish
Summary: BACKGROUND. Polygenic risk score (PRS), calculated based on genome-wide association studies (GWASs), can improve breast cancer (BC) risk assessment. To date, most BC GWASs have...
Year: 2023
Publications
High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer
Institution: University of Nottingham Biodiscovery Institute; Faculty of Medicine, Menoufia University
Keyword(s): inner centromere protein, chromosomal passenger complex, invasive breast cancer, prognosis, METABRIC, TCGA, mRNA
Summary: INTRODUCTION. Inner centromere protein (INCENP) is a member of the chromosomal passenger complex and plays a key role in mitosis and cell proliferation. This study aimed to eval...
Year: 2023
