Publications
Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research
Institution: Swammerdam Institute for Life Sciences, University of Amsterdam
Keyword(s): lineage tracing, single cell analyses, model systems, breast cancer heterogeneity, treatment and recurrence, prevention and early detection
Summary: On 8 December 2022 the organizing committee of the European Network for Breast Development and Cancer labs (ENBDC) held its fifth annual Think Tank meeting in Amsterdam, the Net...
Year: 2023
Publications
Implementing Fully Humanised Methods to Examine How the Endocrine Disrupting Chemical Bisphenol A Contributes to Breast Cancer Development
Institution: University of Aberdeen
Keyword(s): -
Summary: Breast cancer is the most common cancer worldwide, equating to 1 in every 4 cancer diagnoses. Many breast cancer risk factors exist including age, high mammographic density (MD)...
Year: 2023
Publications
Multiscale deep learning framework captures systemic immune features in lymph nodes predictive of triple negative breast cancer outcome in large-scale studies
Institution: King's College London
Keyword(s): immune response, lumph nodes, triple negative breast cancer, deep learning, digitised whole images
Summary: The suggestion that the systemic immune response in lymph nodes (LNs) conveys prognostic value for triple-negative breast cancer (TNBC) patients has not previously been investig...
Year: 2023
Publications
Novel imaging modalities for the detection and characterisation of breast cancer
Institution: University of Aberdeen
Keyword(s): -
Summary: -
Year: 2023
Publications
Prediction models for hormone receptor status in female breast cancer do not extend to males: further evidence of sex-based disparity in breast cancer
Institution: University of Aberdeen
Keyword(s): male breast cancer, multiple instance learning, hormone receptors, computational histopathology
Summary: Breast cancer prognosis and management for both men and women are reliant upon estrogen receptor alpha (ERα) and progesterone receptor (PR) expression to inform therapy. Previou...
Year: 2023
Publications
Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects
Institution: Department of Neurosurgery, University of California San Francisco
Keyword(s): single-cell RNA sequencing, spatial transcriptomics, glioblastoma, cancer associated fibroblasts
Summary: Cancer-associated fibroblasts (CAFs) were presumed absent in glioblastoma given the lack of brain fibroblasts. Serial trypsinization of glioblastoma specimens yielded cells with...
Year: 2023
Publications
TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): 3D in vitro model, ductal carcinoma in situ, luminal cells, myoepithelial cells
Summary: Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would re...
Year: 2023
Publications
Validation of a 3D perfused cell culture platform as a tool for humanised preclinical drug testing in breast cancer using established cell lines and patient-derived tissues
Institution: University of Aberdeen
Keyword(s): 3D cell culture, perfusion, drug response
Summary: 3D cell culture models of cancer are currently being developed to recapitulate in vivo physiological conditions and to assess therapeutic responses. However, most models failed...
Year: 2023
Publications
Virtual alignment of pathology image series for multi-gigapixel whole slide images
Institution: Lee Moffitt Cancer Center and Research Institute
Keyword(s): spatial omics, whole slide images, virtual alignment
Summary: Interest in spatial omics is on the rise, but generation of highly multiplexed images remains challenging, due to cost, expertise, methodical constraints, and access to technolo...
Year: 2023
