Approved Project
Elucidate how immunoediting shapes genetic heterogeneity of healthy breast cells
Keyword(s): Genetics, Immunogenomics, Cancer Evolution, Immunotherapy
Year: 2022
Publications
A biobank perspective on use of tissue samples donated by trial participants
Institution: Institute of Medical Sciences, University of Aberdeen
Keyword(s): -
Summary: As academics closely involved in UK biobanking, we welcome the suggestions made in The Lancet Oncology by Robert Coleman and colleagues 1 to develop guidelines to make the trans...
Year: 2022
Publications
Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
Institution: UCL EGA Institute for Women's Health, University College London; European Translational Oncology Prevention and Screening (EUTOPS) Institute, Universität Innsbruck
Keyword(s): antiprogestins, BRCA1, DNA methylation, epigenetics, field cancerization, intermediate surrogate marker, prevention
Summary: BACKGROUND. Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-progn...
Year: 2022
Publications
Aurora Kinase A Is an independent predictor of invasive recurrence in breast ductal carcinoma in situ
Institution: School of Medicine, University of Nottingham
Keyword(s): Aurora Kinase A, ductal carcinoma in situ, invasive recurrence, poor prognosis
Summary: INTRODUCTION. Aurora Kinase A (AURKA/STK15) has a role in centrosome duplication and is a regulator of mitotic cell proliferation. It is over-expressed in breast cancer and othe...
Year: 2022
Publications
Capture Hi-C to identify regulatory variants and target genes influencing breast cancer risk
Institution: Institute of Cancer Research
Keyword(s): -
Summary: Genome wide association studies have discovered approximately 200 breast cancer risk single nucleotide polymorphisms, most of which map to non-protein-coding regions. To underst...
Year: 2022
Publications
Field cancerization in breast cancer
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): field cancerization, histopathology, genomics, transcriptomics, tumor-adjacent
Summary: Breast cancer affects one in seven women worldwide during their lifetime. Widespread mammographic screening programs and education campaigns allow for early detection of the dis...
Year: 2022
Publications
Incorporating progesterone receptor expression into the PREDICT breast prognostic model
Institution: Department of Oncology, University of Cambridge
Keyword(s): PREDICT Breast, progesterone receptor, prognosis
Summary: BACKGROUND. Predict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast cancer. The aim of this study was to incorporat...
Year: 2022
Publications
Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): ductal carcinoma in situ, myoepithelial cells, progression, recurrence, integrin B6, fibronectin, IHC
Summary: Women with ductal carcinoma in situ (DCIS) have an increased risk of progression to invasive breast cancer. Although not all women with DCIS will progress to invasion, all are t...
Year: 2022
Publications
Obituary - Margaret Wilcox
Institution: School of Medicine Medical Sciences and Nutrition, University of Aberdeen
Keyword(s): -
Summary: -
Year: 2022
