Publications
3-D tissue modelling and virtual pathology as new approaches to study ductal carcinoma in situ
Institution: Leeds Institute of Cancer and Pathology
Keyword(s): 3-D, cell culture, DCIS, virtual pathology
Summary: Widespread screening mammography programmes mean that ductal carcinoma in situ (DCIS), a pre-invasive breast lesion, is now more frequently diagnosed. However, not all diagnosed...
Year: 2015
Publications
Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo
Institution: Department of Biology, University of York
Keyword(s): -
Summary: Voltage-gated Na+ channels (VGSCs) mediate action potential firing and regulate adhesion and migration in excitable cells. VGSCs are also expressed in cancer cells. In metastati...
Year: 2015
Publications
Transcriptional implications of intragenic DNA methylation in the oestrogen receptor alpha gene in breast cancer cells and tissues
Institution: Faculty of Medicine, Imperial College London
Keyword(s): epigenetics, DNA methylation, ESR1
Summary: BACKGROUND. DNA methylation variability regions (MVRs) across the oestrogen receptor alpha (ESR1) gene have been identified in peripheral blood cells from breast cancer patients...
Year: 2015
Publications
Adding value to rare tissue samples donated to biobanks: characterisation of breast tissue and primary cell cultures obtained from a female-to-male transgender patient
Institution: Leeds Institute of Cancer and Pathology, University of Leeds
Keyword(s): IHC, biobank, f-to-m transgender tissue
Summary: Biobanks provide a window of opportunity to store and add value to material from rare cases allowing their future use in biomedical research. One such example is the opportunity...
Year: 2014
Publications
BCCTBbp: the Breast Cancer Campaign Tissue Bank bioinformatics portal
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): bioinformatics, genomics, transcriptomics, BCNTB data
Summary: BCCTBbp was initially developed as the data-mining portal of the Breast Cancer Campaign Tissue Bank (BCCTB), a vital resource of breast cancer tissue for researchers to support...
Year: 2014
Publications
The sodium channel β1 subunit mediates outgrowth of neurite-like processes on breast cancer cells and promotes tumour growth and metastasis
Institution: Department of Biology, University of York
Keyword(s): transcriptomics, IHC, ICC, orthotopic model, sodium channel β1 subunit
Summary: Voltage-gated Na+ channels (VGSCs) are heteromeric proteins composed of pore-forming α subunits and smaller β subunits. The β subunits are multifunctional channel modulators and...
Year: 2014
Publications
Breast cancer: Investment biobanking--increased returns from tissue samples
Institution: Leeds Institute of Molecular Medicine, University of Leeds
Keyword(s): biobanks, samples, data return, Independent Cancer Patients' Voice
Summary: Researchers now expect that samples obtained from biobanks are accompanied with well-annotated clinical data. Opened in 2010, the Breast Cancer Campaign Tissue Bank takes this c...
Year: 2013
Approved Project
3D perfused model for breast cancer modelling and therapeutic screening
Keyword(s): 3D perfusion culture, ER+ breast cancer, drug screening
Year: Legacy
Approved Project
Analysis of CIZl alternative splicing in breast cancer cells
Keyword(s): CIZ1, alternative splicing, epigenetics
Year: Legacy
