Publications
Tumour promoting HER2 splice variant Δ16HER2: Regulation and implication in breast cancer
Institution: Newcastle University Institute of Cellular Medicine
Keyword(s): pre-mRNA, HER2, IHC
Summary: Results from high-throughput studies of the last decade have shown an important connection between regulated pre-mRNA splicing and tumorigenesis as well as therapy resistance. T...
Year: 2017
Publications
Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer
Institution: Division of Cancer, Imperial College Faculty of Medicine
Keyword(s): metastasis, cancer stem cells, drug resistance, BCL2, ABCG2, EP300 signature
Summary: Purpose: We have previously described a novel pathway controlling drug resistance, epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer cells. Upstream in th...
Year: 2017
Publications
A 3D in vitro model of the human breast duct: unravelling myoepithelial-luminal interactions in breast cancer
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): -
Summary: -
Year: 2016
Publications
A comparative study of male versus female breast cancer identifies overexpression of eiF signalling pathways in male breast cancer providing opportunities for a therapeutic window
Institution: Leeds Institute of Cancer and Pathology, University of Leeds
Keyword(s): -
Summary: -
Year: 2016
Publications
An evaluation of matrix-containing and humanised matrix-free 3-dimensional cell culture systems for studying breast cancer
Institution: Leeds Institute of Cancer and Pathology, University of Leeds
Keyword(s): -
Summary: BACKGROUND. 3D cell cultures are emerging as more physiologically meaningful alternatives to monolayer cultures for many biological applications. They are attractive because the...
Year: 2016
Publications
Breast Cancer Now Cell Culture Programme: a bespoke resource for the research community
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): -
Summary: -
Year: 2016
Publications
Expression of CDK7, Cyclin H, and MAT1 is elevated in breast cancer and is prognostic in estrogen receptor-positive breast cancer
Institution: Department of Surgery and Cancer, Imperial College London
Keyword(s): -
Summary: Purpose: CDK-activating kinase (CAK) is required for the regulation of the cell cycle and is a trimeric complex consisting of cyclin-dependent kinase 7 (CDK7), Cyclin H, and the...
Year: 2016
Publications
Management of breast cancer in an Asian man with post-traumatic stress disorder: a case report
Institution: Leeds Institute of Cancer and Pathology, University of Leeds
Keyword(s): male breast cancer, ethnicity, Afghan, PTSD
Summary: BACKGROUND. Migration to the UK has increased considerably, which is reflected in the diverse multicultural population which includes asylum seekers and economic migrants. Diffe...
Year: 2016
Publications
The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis
Institution: Cancer Research UK Beatson Institute
Keyword(s): initiator methionine tRNA (tRNAiMet), extracellular matrix, tumor angiogenesis, secretome, tRNA repertoire, cell migration, tumor stroma
Summary: Expression of the initiator methionine tRNA (tRNAiMet) is deregulated in cancer. Despite this fact, it is not currently known how tRNAiMet expression levels influence tumor prog...
Year: 2016
