Publications
Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers
Institution: University of Nottingham
Keyword(s): -
Summary: Impaired DNA repair drives mutagenicity, which increases neoantigen load and immunogenicity. We investigated the expression of proteins involved in the DNA damage response (ATM,...
Year: 2017
Publications
Epigenomic profiling of oestrogen receptor-positive breast cancer
Institution: Department of Surgery and Cancer, Imperial College London
Keyword(s): -
Summary: Endocrine resistance occurs in the majority of patients who have relapsing breast cancer which remains a challenge to current medical treatment. Tumour heterogeneity poses an ob...
Year: 2017
Publications
Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): CRISPR-Cas systems, DNA methylation, tumour-suppressor proteins
Summary: Aberrant promoter DNA hypermethylation is a hallmark of cancer; however, whether this is sufficient to drive cellular transformation is not clear. To investigate this question,...
Year: 2017
Publications
How is Herstatin, a tumor suppressor splice variant of the oncogene HER2, regulated?
Institution: Faculty of Medical Sciences, Newcastle University
Keyword(s): HER2 splice variants, oncogene HER2/erbB-2, RNA-binding proteins
Summary: The human epidermal growth factor receptor 2 (HER2)/receptor tyrosine-protein kinasebB-2 (ERBB2) is overexpressed in 20-30% of breast tumors leading to faster growing and more a...
Year: 2017
Publications
Ki67 expression in invasive breast cancer: the use of tissue microarrays compared with whole tissue section
Institution: School of Medicine, University of Nottingham
Keyword(s): Ki67, immunohistochemistry, prognosis, METABRIC
Summary: BACKGROUND. Although the prognostic value of Ki67 in breast cancer is well documented, using optimal cut-points for patient stratification, reproducibility of the scoring and in...
Year: 2017
Publications
Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): ductal carcinoma in situ, myoepithelial cell, microenvironment, MMP-8, adhesion, hemidesmosomes, organotypic assays, invasion
Summary: BACKGROUND. Normal myoepithelial cells (MECs) play an important tumour-suppressor role in the breast but display an altered phenotype in ductal carcinoma in situ (DCIS), gaining...
Year: 2017
Publications
POPDC1 is suppressed in human breast cancer tissues and is negatively regulated by EGFR in breast cancer cell lines
Institution: School of Medicine Medical Sciences and Nutrition, University of Aberdeen
Keyword(s): -
Summary: Breast cancer molecular heterogeneity has resulted in disparities in therapeutic response and targeting of molecular subtypes of breast cancer. This necessitates identification...
Year: 2017
Publications
Rho-GTPase activating-protein 18: a biomarker associated with good prognosis in invasive breast cancer
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): ARHGAP18, lymphovascular invasion, immunohistochemistry, prognosis
Summary: BACKGROUND. The prognostic value of lymphovascular invasion (LVI) in breast cancer (BC) has been demonstrated in several independent studies. However, identification of driver m...
Year: 2017
Publications
The role of microRNAs in the fibroblasts of triple negative and basal-like breast cancer
Institution: Faculty of Medicine and Health, University of Leeds
Keyword(s): fibroblast basal microRNA miR-21
Summary: Breast cancer is the second most common cancer worldwide and the fifth biggest cause of cancer-related deaths. Breast cancer subtype has a huge influence on tumour behaviour and...
Year: 2017
