Publications
Stanniocalcin 2 expression is associated with a favourable outcome in male breast cancer
Institution: Leeds Institute of Cancer and Pathology, University of Leeds
Keyword(s): male breast cancer, stanniocalcin 2, immunohistochemistry, survival
Summary: Breast cancer can occur in either gender; however, it is rare in men, accounting for <1% of diagnosed cases. In a previous transcriptomic screen of male breast cancer (MBC) and...
Year: 2018
Publications
The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours
Institution: School of Medicine, University of Nottingham
Keyword(s): SLC7A5, prognosis
Summary: BACKGROUND. Breast cancer (BC) is a heterogeneous disease characterised by variant biology and patient outcome. The amino acid transporter, SLC7A5, plays a role in BC although i...
Year: 2018
Publications
The multifunctional solute carrier 3A2 (SLC3A2) confers a poor prognosis in the highly proliferative breast cancer subtypes
Institution: School of Medicine, University of Nottingham
Keyword(s): -
Summary: Breast cancer (BC) is a heterogeneous disease characterised by variant biology, metabolic activity and patient outcome. This study aimed to evaluate the biological and prognosti...
Year: 2018
Publications
The significance of tumour microarchitectural features in breast cancer prognosis: a digital image analysis
Institution: Oxford University; Institute of Cancer Research
Keyword(s): digital image analysis, prognosis, microarchitecture, tumour nests
Summary: BACKGROUND. As only a minor portion of the information present in histological sections is accessible by eye, recognition and quantification of complex patterns and relationship...
Year: 2018
Publications
Thioredoxin-interacting protein is an independent risk stratifier for breast ductal carcinoma in situ
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): -
Summary: Current clinicopathological parameters are useful predictors of breast ductal carcinoma in situ behavior, but they are insufficient to define high-risk patients for disease prog...
Year: 2018
Publications
A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): 3D model, ductal carcinoma in situ, myoepithelial cells, luminal cells
Summary: 3D modelling fulfils a critical role in research, allowing for complex cell behaviour and interactions to be studied in physiomimetic conditions. With tissue banks becoming esta...
Year: 2017
Publications
A case-matched gender comparison transcriptomic screen identifies eIF4E and eIF5 as potential prognostic markers in male breast cancer
Institution: Leeds Institute of Cancer and Pathology, University of Leeds
Keyword(s): -
Summary: Purpose: Breast cancer affects both genders, but is understudied in men. Although still rare, male breast cancer (MBC) is being diagnosed more frequently. Treatments are wholly...
Year: 2017
Publications
BCNTB bioinformatics: the next evolutionary step in the bioinformatics of breast cancer tissue banking
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): bioinformatics, genomics, transcriptomics, BCNTB data
Summary: Here, we present an update of Breast Cancer Now Tissue Bank bioinformatics, a rich platform for the sharing, mining, integration and analysis of breast cancer data. Its modaliti...
Year: 2017
Publications
CIP2A expression predicts recurrences of tamoxifen-treated breast cancer
Institution: Faculty of Medicine and Surgery, University of Malta
Keyword(s): CIP2A, tamoxifen resistance, immunohistochemistry, tissue microarrays
Summary: CIP2A is emerging as an oncoprotein overexpressed commonly across many tumours and generally correlated with higher tumour grade and therapeutic resistance. CIP2A drives an onco...
Year: 2017
