Publications
Immune infiltration in invasive lobular breast cancer
Institution: Breast Cancer Translational Research Laboratory (BCTL), Institut Jules Bordet
Keyword(s): invasive lobular breast carcinoma, tumor-infiltrating lymphocytes
Summary: BACKGROUND. Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after invasive ductal cancer (IDC). Here, we aimed at evaluating...
Year: 2018
Publications
Immunopeptidomic profiling of HLA-A2-positive triple negative breast cancer identifies potential immunotherapy target antigens
Institution: Radcliffe Department of Medicine, University of Oxford
Keyword(s): proteomics, triple negative breast cancer
Summary: The recent development in immune checkpoint inhibitors and chimeric antigen receptor (CAR) T-cells in the treatment of cancer has not only demonstrated the potency of utilizing...
Year: 2018
Publications
Impact of breast cancer grade discordance on prediction of outcome
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): agreement, breast pathology, discordance, grade, outcome
Summary: AIMS. Histological grade is an independent prognostic variable in breast cancer (BC). Previous concordance studies of BC grade have reported moderate levels of agreement; a typi...
Year: 2018
Publications
MYC regulation of glutamine-proline regulatory axis is key in luminal B breast cancer
Institution: School of Medicine, University of Nottingham
Keyword(s): metabolism, prognosis, Luminal B, glutamine, proline
Summary: BACKGROUND. Altered cellular metabolism is a hallmark of cancer and some are reliant on glutamine for sustained proliferation and survival. We hypothesise that the glutamine-pro...
Year: 2018
Publications
Mechanostimulation of integrin αvβ6 and fibronectin in DCISmyoepithelial cells
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): -
Summary: Alterations to the tumour microenvironment is a common feature of many cancers, including breast cancer, and there is increasing evidence that alterations to the microenvironmen...
Year: 2018
Publications
Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes
Institution: School of Medicine, University of Nottingham
Keyword(s): -
Summary: BACKGROUND. Mediator complex (MED) proteins have a key role in transcriptional regulation, some interacting with the oestrogen receptor (ER). Interrogation of the METABRIC cohor...
Year: 2018
Publications
Prognostic significance of tumor-infiltrating lymphocytes in ductal carcinoma in situ of the breast.
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): -
Summary: Tumor-infiltrating lymphocytes (TILs) provide prognostic value in invasive breast cancer and guidelines for their assessment have been published. This study aims to evaluate: (a...
Year: 2018
Publications
Prolyl-4-hydroxylase Α subunit 2 (P4HA2) expression is a predictor of poor outcome in breast ductal carcinoma in situ (DCIS)
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): -
Summary: BACKGROUND. Extracellular matrix (ECM) plays a crucial role in tumour behaviour. Prolyl-4-hydroxlase-A2 (P4HA2) is a key enzyme in ECM remodelling. This study aims to evaluate t...
Year: 2018
Publications
Saccharomyces cerevisiae-like 1 (SEC14L1) is a prognostic factor in breast cancer associated with lymphovascular invasion
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): -
Summary: Lymphovascular invasion is strongly related to breast cancer metastasis. However, the underlying mechanisms of lymphovascular invasion and its driver molecules in breast cancer...
Year: 2018
