Publications
Co-expression of nuclear P38 and hormone receptors is prognostic of good long-term clinical outcome in primary breast cancer and is linked to upregulation of DNA repair
Institution: School of Medicine, University of Nottingham
Keyword(s): P38, MAPK, oestrogen receptor, adjuvant, survival, prognosis
Summary: BACKGROUND. P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to th...
Year: 2018
Publications
Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers
Institution: Barts Cancer Institute, Queen Mary University of London; Francis Crick Institute
Keyword(s): -
Summary: We have profiled, for the first time, an evolving human metastatic microenvironment by measuring gene expression, matrisome proteomics, cytokine and chemokine levels, cellularit...
Year: 2018
Publications
Dual mechanisms of LYN kinase dysregulation drive aggressive behavior in breast cancer cells
Institution: European Cancer Stem Cell Research Institute, Cardiff University
Keyword(s): -
Summary: The SRC-family kinase LYN is highly expressed in triple-negative/basal-like breast cancer (TNBC) and in the cell of origin of these tumors, c-KIT-positive luminal progenitors. H...
Year: 2018
Publications
Electrophysiological characterisation of ion channel activity in tumour slices
Institution: University of York
Keyword(s): -
Summary: -
Year: 2018
Publications
Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer
Institution: Imperial Centre for Translational and Experimental Medicine, Imperial College London
Keyword(s): -
Summary: The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumor evolution is poorly understood. Phenotypic drifts can be transmitted via inheritable tran...
Year: 2018
Publications
Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer
Institution: Institute of Cancer Research
Keyword(s): -
Summary: Disruption of Cyclin-Dependent Kinase 12 (CDK12) is known to lead to defects in DNA repair and sensitivity to platinum salts and PARP1/2 inhibitors. However, CDK12 has also been...
Year: 2018
Publications
Exploring the roles of the Protein Kinase N family in breast cancer
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): -
Summary: Solid tumours are composed of cancer cells and a variety of other cell types, forming the tumour microenvironment (TME). Cells within the TME promote cell survival, proliferatio...
Year: 2018
Publications
Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study
Institution: Cancer Sciences Academic Unit, University of Southampton
Keyword(s): POSH study, germline mutations, BRCA1, BRCA2, young-onset, retrospective
Summary: BACKGROUND. Retrospective studies provide conflicting interpretations of the effect of inherited genetic factors on the prognosis of patients with breast cancer. The primary aim...
Year: 2018
Publications
Heterogeneity of tumour‐infiltrating lymphocytes in breast cancer and its prognostic significance
Institution: School of Medicine, University of Nottingham
Keyword(s): heterogeneity, outcome, tumour-infiltrating lymphocytes
Summary: BACKGROUND. Tumour-infiltrating lymphocytes (TILs) in breast cancer (BC) provide prognostic and predictive information. The aim of this study was to assess the spatial and tempo...
Year: 2018
