Publications
The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor
Institution: Lund University; Umeå University
Keyword(s): predictive markers
Summary: Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related death...
Year: 2019
Publications
Utility of ankyrin 3 as a prognostic marker in androgen-receptor-positive breast cancer.
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufyia University
Keyword(s): invasive breast cancer, androgen receptor, Ankyrin 3, prognostic marker
Summary: PURPOSE. Androgen receptor (AR) and AR signaling pathways are thought to play a role in breast cancer (BC) and are potentially related to treatment responses and outcomes. Ankyr...
Year: 2019
Publications
An engineered human adipose/collagen model for in vitro breast cancer cell migration studies
Institution: Department of Pathology, University of Cambridge
Keyword(s): mesenchymal stem cells, adipocytes, anisotropic, collagen, immortalization
Summary: Adipocytes are one of the major stromal cell components of the human breast. These cells play a key role in the development of the gland and are implicated in breast tumorigenes...
Year: 2018
Publications
Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): clonality, stem cells, mammary stem cell niche, ductal carcinomain situ
Summary: It is widely accepted that the cell of origin of breast cancer is the adult mammary epithelial stem cell; however, demonstrating the presence and location of tissue stem cells i...
Year: 2018
Publications
BQ323636.1, a novel splice variant to NCOR 2, as a predictor for tamoxifen-resistant breast cancer
Institution: Li Ka Shing Faculty of Medicine, University of Hong Kong
Keyword(s): -
Summary: Purpose: Adjuvant tamoxifen treatment revolutionized the management of estrogen receptor (ER)-positive breast cancers to prevent cancer recurrence; however, drug resistance comp...
Year: 2018
Publications
Breast cancer histologic grading using digital microscopy: concordance and outcome association
Institution: School of Medicine, University of Nottingham
Keyword(s): -
Summary: BACKGROUND. Virtual microscopy utilising digital whole slide imaging (WSI) is increasingly used in breast pathology. Histologic grade is one of the strongest prognostic factors...
Year: 2018
Publications
Characterising the adipose-inflammatory microenvironment in male breast cancer
Institution: Leeds Institute of Cancer and Pathology, University of Leeds
Keyword(s): male breast cancer, gynaecomastia, adipocytes, crown-like structures, microenvironment
Summary: Male breast cancer (MBC) incidence seems to parallel global increases in obesity. The stromal microenvironment contributes to carcinogenesis; yet, the role of adipocytes in this...
Year: 2018
Publications
Clinical and biological roles of Kelch-like family member 7 in breast cancer: a marker of poor prognosis
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): invasive breast cancer, lymphovascular invasion, prognosis, Kelch-like family member 7 (KLHL7), ubiquitination
Summary: BACKGROUND. The functions of many proteins are tightly regulated with a complex array of cellular functions including ubiquitination. In cancer cells, aberrant ubiquitination ma...
Year: 2018
Publications
Clinicopathological and prognostic significance of Ras association and pleckstrin homology domains 1 (RAPH1) in breast cancer
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): invasive breast cancer, lymphovascular invasion, ras association and pleckstrin homology domains 1, re-epithelialisation, E-cadherin
Summary: BACKGROUND. Ras association and pleckstrin homology domains 1 (RAPH1) is involved in cytoskeleton regulation and re-epithelialisation in invasive carcinoma and, therefore, may p...
Year: 2018
