Publications
Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ
Institution: School of Medicine, University of Nottingham
Keyword(s): Cathepsin V, ductal carcinoma in situ, proteolysis, recurrence, stroma
Summary: AIMS. Cathepsin V (CTSV/CTSL2) is a lysosomal cysteine proteinase and plays a role in extracellular matrix degradation. It is associated with poor prognosis in invasive breast c...
Year: 2019
Publications
Retinoid X receptor gamma (RXRG) is an independent prognostic biomarker in ER-positive invasive breast cancer
Institution: School of Medicine, University of Nottingham
Keyword(s): prognostic markers
Summary: BACKGROUND. Retinoid X Receptor Gamma (RXRG) is a member of the nuclear receptor superfamily and plays a role in tumour suppression. This study aims to explore the prognostic si...
Year: 2019
Publications
SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment
Institution: Northeast Normal University; Auckland University of Technology
Keyword(s): molecular medicine, predictive markers, prognostic markers
Summary: BACKGROUND. SHON nuclear expression (SHON-Nuc+) was previously reported to predict clinical outcomes to tamoxifen therapy in ERα+ breast cancer (BC). Herein we determined if SHO...
Year: 2019
Publications
SMAC, a computational system to link literature, biomedical and expression data
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): data mining, literature mining
Summary: High-throughput technologies have produced a large amount of experimental and biomedical data creating an urgent need for comprehensive and automated mining approaches. To meet...
Year: 2019
Publications
The clinical and biological significance of HER2 over-expression in breast ductal carcinoma in situ: a large study from a single institution
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): oncogenesis
Summary: BACKGROUND. Previous studies have reported up to 50% of ductal carcinoma in situ (DCIS), is HER2 positive, but the frequency of HER2-positive invasive breast cancer (IBC) is low...
Year: 2019
Publications
The combined expression of solute carriers is associated with a poor prognosis in highly proliferative ER+ breast cancer
Institution: School of Medicine, University of Nottingham
Keyword(s): SLC1A5, SLC7A5, SLC3A2, clusters, prognosis
Summary: PURPOSE. Breast cancer (BC) is a heterogeneous disease characterised by variant biology, metabolic activity, and patient outcome. Glutamine availability for growth and progressi...
Year: 2019
Publications
The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts
Institution: School of Medicine, University of Nottingham
Keyword(s): -
Summary: E-cadherin is a tumor suppressor gene in invasive lobular breast cancer. However, a proportion of high-grade ductal carcinoma shows reduced/loss of E-cadherin. In this study, we...
Year: 2019
Publications
The prognostic significance of lysosomal protective protein (cathepsin A) in breast ductal carcinoma in situ
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): -
Summary: AIMS. Cathepsin A (CTSA) is a key regulatory enzyme for galactoside metabolism. Additionally, it has a distinct proteolytic activity and plays a role in tumour progression. CTSA...
Year: 2019
Publications
The prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): IDH2, lymphovascular invasion, prognosis, progression
Summary: BACKGROUND. Lymphovascular invasion (LVI) is a prerequisite step in breast cancer (BC) metastasis. We have previously identified wild-type isocitrate dehydrogenase 2 (IDH2) as a...
Year: 2019
