Publications
Geometric characteristics of collagen have independent prognostic significance in breast ductal carcinoma in situ: an image analysis study
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): -
Summary: Collagen plays a key role in normal and malignant tissue homeostasis. While the prognostic significance of collagen fiber remodeling in invasive breast cancer has been studied,...
Year: 2019
Publications
Glutamate dehydrogenase (GLUD1) expression in breast cancer
Institution: School of Medicine, University of Nottingham
Keyword(s): GLUD1, prognosis, triple negative, glutamine, metabolism
Summary: BACKGROUND. Dysregulated cellular metabolism is one of the hallmarks of cancer with some tumours utilising the glutamine metabolism pathway for their sustained proliferation and...
Year: 2019
Publications
Heparanase-dependent remodeling of initial lymphatic glycocalyx regulates tissue-fluid drainage during acute inflammation in vivo
Institution: William Harvey Research Institute, Queen Mary University of London
Keyword(s): glycocalyx, lymphatic vessels, neutrophil trafficking, inflammation, lectins, heparan sulfate, heparanase, lymphatic drainage
Summary: The glycocalyx is a dense layer of carbohydrate chains involved in numerous and fundamental biological processes, such as cellular and tissue homeostasis, inflammation and disea...
Year: 2019
Publications
Investigation of hormone signalling and breast epithelial hierarchy in women at a high risk of cancer
Institution: University of Manchester
Keyword(s): hormones, epithelia, epithelial hierarchy, high-risk, estrogen, progesterone
Summary: Estrogen, progesterone and prolactin help control human breast development. Hormonal signalling is a known breast cancer risk factor, but little is known about how increased ris...
Year: 2019
Publications
Kinesin family member-18A (KIF18A) is a predictive biomarker of poor benefit from endocrine therapy in early ER+ breast cancer
Institution: School of Medicine, University of Nottingham
Keyword(s): oestrogen receptor, endocrine treatment, predictive biomarker, KIF18A
Summary: PURPOSE. Identification of effective and reliable biomarkers that could be used to predict the efficacy of endocrine therapy is of crucial importance to the management of oestro...
Year: 2019
Publications
Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): -
Summary: Legumain is a proteolytic enzyme that plays a role in the regulation of cell proliferation in invasive breast cancer. Studies evaluating its role in ductal carcinoma in situ (DC...
Year: 2019
Publications
Oncogenic EP300 can be targeted with inhibitors of aldo-keto reductases
Institution: Division of Cancer, Imperial College Faculty of Medicine
Keyword(s): -
Summary: E-cadherin transcriptional activator EP300 is down-regulated in metaplastic breast carcinoma, a rare form of triple negative and E-cadherin-negative aggressive breast cancer wit...
Year: 2019
Publications
Overexpression of the cancer stem cell marker CD133 confers a poor prognosis in invasive breast cancer
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): cancer stem cell, invasive breast cancer, prognosis, CD133
Summary: PURPOSE. CD133/ prominin 1 is a cancer stem cell marker associated with cancer progression and patient outcome in a variety of solid tumours, but its role in invasive breast can...
Year: 2019
Publications
Prognostic role of androgen receptor in triple negative breast cancer: a multi-institutional study
Institution: Georgia State University
Keyword(s): androgen receptor, triple-negative breast cancer, prognosis, multi-institutional study
Summary: Background: The androgen receptor (AR) has emerged as a potential therapeutic target for AR-positive triple-negative breast cancer (TNBC). However, conflicting reports regarding...
Year: 2019
