Publications
Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers
Institution: University of Nottingham
Keyword(s): ATM, ATR, MYC
Summary: PURPOSE. MYC transcription factor has critical roles in cell growth, proliferation, metabolism, differentiation, transformation and angiogenesis. MYC overexpression is seen in a...
Year: 2019
Publications
Clinicopathological significance of lipocalin 2 nuclear expression in invasive breast cancer
Institution: University of Nottingham
Keyword(s): basal type, epithelial-mesenchymal transition, lipocalin 2, N-cadherin
Summary: PURPOSE. The epithelial-mesenchymal transition (EMT) plays a key role in breast cancer progression and metastasis. Lipocalin 2 (LCN2) is involved in the regulation of EMT. The a...
Year: 2019
Publications
Collagen (XI) alpha-1 chain is an independent prognostic factor in breast ductal carcinoma in situ
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): -
Summary: Collagen11A1 (COL11A1) is a fibrillary type collagen constituting a minor component of the extracellular matrix and plays role in tissue tensile strength. Overexpression of COL1...
Year: 2019
Publications
Connexin 43 is an independent predictor of patient outcome in breast cancer patients
Institution: University of Nottingham
Keyword(s): Connexin 43, tissue microarray, tumor biomarker
Summary: PURPOSE. Gap junctions are specialized membrane structures that form channels between adjacent cells allowing cell communication. Gap junctions and specifically Connexin 43 (Cx4...
Year: 2019
Publications
ERCC1 Is a predictor of anthracycline resistance and taxane sensitivity in early stage or locally advanced breast cancers
Institution: University of Nottingham
Keyword(s): ERCC1, anthracycline resistance, taxane sensitivity
Summary: Genomic instability could be a beneficial predictor for anthracycline or taxane chemotherapy. We interrogated 188 DNA repair genes in the METABRIC cohort (n = 1980) to identify...
Year: 2019
Publications
Epigenetic mechanisms of breast cancer prevention by the Type II diabetes mellitus agent metformin
Institution: Department of Surgery and Cancer Publisher, Imperial College London
Keyword(s): -
Summary: Breast cancer is the most commonly diagnosed cancer in the UK. Long-term use of metformin, a drug used to treat Type II Diabetes Mellitus, has been linked to a reduced risk of b...
Year: 2019
Publications
Epigenomic and genomic dissection of oestrogen receptor-positive breast cancer
Institution: Department of Surgery and Cancer, Imperial College London
Keyword(s): -
Summary: Genetic and Epigenetic mechanisms underlie the natural complexity of phenotypical and morphological aspects of cancer. Extensive phenotypical intra and inter-patient heterogenei...
Year: 2019
Publications
Expression of Lamin A/C in early-stage breast cancer and its prognostic value
Institution: School of Medicine, University of Nottingham
Keyword(s): Lamin A/C, immunohistochemistry, tissue microarray, prognosis
Summary: PURPOSE. Lamins A/C, a major component of the nuclear lamina, play key roles in maintaining nuclear integrity, regulation of gene expression, cell proliferation and apoptosis. R...
Year: 2019
Publications
Genome-wide association study of germline variants and breast cancer-specific mortality
Institution: University of Cambridge
Keyword(s): cancer genetics, prognosis, prognostic markers
Summary: BACKGROUND. We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS. Meta-analyses...
Year: 2019
