Publications
The prognostic significance of immune microenvironment in breast ductal carcinoma in situ
Institution: School of Medicine, University of Nottingham
Keyword(s): -
Summary: BACKGROUND. The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to asses...
Year: 2020
Publications
The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer
Institution: School of Medicine, University of Nottingham
Keyword(s): prognosis, SLC7A8, ER+ breast cancer
Summary: PURPOSE. Breast cancer (BC) is a heterogeneous disease consisting of various subtypes, with different prognostic and therapeutic outcomes. The amino acid transporter, SLC7A8, is...
Year: 2020
Publications
Visual histological assessment of morphological features reflects the underlying molecular profile in invasive breast cancer: a morphomolecular study
Institution: School of Medicine, University of Nottingham
Keyword(s): digital pathology, grade, molecular profiles, morphology
Summary: AIMS. Tumour genotype and phenotype are related and can predict outcome. In this study, we hypothesised that the visual assessment of breast cancer (BC) morphological features c...
Year: 2020
Publications
XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib
Institution: University of Nottingham
Keyword(s): ATM, ATR, AZ31, AZD1775, AZD6738, DNA repair, PARP, Wee1, XRCC1, olaparib, synthetic lethality, triple negative breast cancer
Summary: PARP inhibitor (PARPi) monotherapy is a new strategy in BRCA germ-line deficient triple negative breast cancer (TNBC). However, not all patients respond, and the development of...
Year: 2020
Publications
A key genomic subtype associated with lymphovascular invasion in invasive breast cancer
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufyia University
Keyword(s): cancer genomics
Summary: BACKGROUND. Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, whic...
Year: 2019
Publications
Are baseline ultrasound and mammographic features associated with rates of pathological completes response in patients receiving neoadjuvant chemotherapy for breast cancer?
Institution: University of Dundee
Keyword(s): mammography, neoadjuvant chemotherapy, pathological complete response, ultrasound
Summary: BACKGROUND. Increasing numbers of breast cancer patients receive neoadjuvant chemotherapy (NACT). We seek to investigate whether baseline mammographic and ultrasound features ar...
Year: 2019
Publications
Atypical ductal hyperplasia is a multipotent precursor of breast carcinoma
Institution: Peter MacCallum Cancer Centre; University of Melbourne
Keyword(s): -
Summary: The current model for breast cancer progression proposes independent 'low grade (LG)-like' and 'high grade(HG)-like' pathways but lacks a known precursor to HG cancer. We applie...
Year: 2019
Publications
CDC20 expression in oestrogen receptor positive breast cancer predicts poor prognosis and lack of response to endocrine therapy
Institution: School of Medicine, University of Nottingham
Keyword(s): CDC20, ER, endocrine resistance, predictive biomarker
Summary: PURPOSE. Endocrine therapy is the standard treatment for oestrogen receptor positive (ER+) breast cancer. Despite its efficacy, around half of patients will develop resistance t...
Year: 2019
Publications
Clinicopathological characteristics of Basal-like Breast Cancer (BLBC): a comparative study between Egyptian and British patients
Institution: Faculty of Medicine, Assiut University
Keyword(s): basal like, British patients, comparative study, Egyptian
Summary: BACKGROUND. Clinicopathological features of basal-like breast cancer (BLBC) in African-American women have been extensively studied. Comparatively, less is known about these tum...
Year: 2019
