Publications
A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast
Institution: Department of Pharmacology, University of Cambridge
Keyword(s): ageing, bioinformatics
Summary: Here we use single-cell RNA sequencing to compile a human breast cell atlas assembled from 55 donors that had undergone reduction mammoplasties or risk reduction mastectomies. F...
Year: 2024
Publications
Multi-modal AI for comprehensive breast cancer prognostication
Institution: Ataraxis A; Center for Data Science, NYU; Grossman School of Medicin, NYU
Keyword(s): AI
Summary: Treatment selection in breast cancer is guided by molecular subtypes and clinical characteristics. Recurrence risk assessment plays a crucial role in personalizing treatment. Cu...
Year: 2024
Publications
Stromal lymphocytes are associated with upgrade of B3 breast lesions
Institution: Peter MacCallum Cancer Centre; University of Melbourne
Keyword(s): histopathological, clinical, imaging, stromal lymphocytes, B3 breast lesions
Summary: Various histopathological, clinical and imaging parameters have been evaluated to identify a subset of women diagnosed with lesions with uncertain malignant potential (B3 or BIR...
Year: 2024
Publications
The Lancet Breast Cancer Commission
Institution: Department of Oncology, University of Cambridge, Cambridge, UK
Keyword(s): -
Summary: The Lancet Breast Cancer Commission-a diverse, multidisciplinary international group-are unanimous in our determination to improve the lives of all people who live with or are a...
Year: 2024
Publications
The amino acid transporter SLC7A11 expression in breast cancer
Institution: School of Medicine, University of Nottingham
Keyword(s): IHC, SLC7A11, amino acid transporters, metabolism, prognostic factor, subtypes, genomic, transcriptomic, protein
Summary: Breast cancer (BC), characterized by its diverse molecular profiles and clinical outcomes, presents a significant challenge in the development of effective therapeutic strategie...
Year: 2024
Publications
Vitacrystallography: Structural Biomarkers of Breast Cancer Obtained by X-ray Scattering
Institution: City University of New York
Keyword(s): structural biomarkers, X-ray scattering, extracellular matrix, cancer detection, machine learning
Summary: With breast cancer being one of the most widespread causes of death for women, there is an unmet need for its early detection. For this purpose, we propose a non-invasive approa...
Year: 2024
Approved Project
Identifying genetic prognostic markers that predict relapse/metastasis
Keyword(s): Therapy resistance, recurrence, predictive prognostic markers
Year: 2023
Approved Project
Establishing breast cancer PDX models
Keyword(s): PDX models, LILRB3, myeloid immune checkpoint
Year: 2023
Approved Project
Capture Hi-C approach to characterising mammographic density, breast size and breast cancer loci in primary cells
Keyword(s): Capture Hi-C, mammographic density, GWAS loci
Year: 2023