Role of IKK alpha in TNBC
Institution: University of Glasgow
Corresponding Researcher: Joanne Edwards
Publication Link(s): https://theses.gla.ac.uk/82388/ Khongthong, Phungern (2021) The role of IKKalpha and IKKalpha phosphorylation in breast cancer. PhD thesis, University of Glasgow.
Data Link(s): NA
Keyword(s): IHC
Summary
NF-κB has been demonstrated to be a key transcription factor that links inflammation and cancer. Several members of the NF-κB family have been investigated and were reported to be overexpressed in breast cancer cell lines and in breast cancer tissue. IKKα, a key catalytic component of the non-canonical NF-κB pathway have been reported to be involved in development of breast cancer and treatment resistance. The aim of the current study was to investigate the role of IKKα and two phosphorylation sites, serine 176 (pIKKα-Ser176) and threonine 23 (pIKKα-Thr23), in different breast cancer subtypes, particularly TNBC. The role of NIK and phosphor-AKT, which is responsible for IKKα activation at serine 176 and threonine 23, respectively, was also investigated.
