Publications
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers
Institution: Institute of Cancer Research
Keyword(s): cancer epidemiology, cancer genetics
Summary: BACKGROUND. Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify gen...
Year: 2021
Publications
Cancer-associated fibroblasts induce an aggressive phenotypic shift in non-malignant breast epithelial cells via interleukin-8 and S100A8
Institution: College of Pharmacy, Duksung Women's University
Keyword(s): cancer-associated fibroblasts, MCF10A, S100A8, MDA-MB-231, cancer-adjacent
Summary: Cancer-associated fibroblasts (CAFs) in the tumor microenvironment have been associated with tumor progression in breast cancer. Although crosstalk between breast cancer cells a...
Year: 2021
Publications
Combined associations of a polygenic risk score and classical risk factors with breast cancer risk. JNCI: Journal of the National Cancer Institute
Institution: German Cancer Research Center (DKFZ); University Cancer Center Hamburg (UCCH)
Keyword(s): estrogen receptors, goodness of fit, genetic risk, breast cancer risk, prevention, lifetime risk
Summary: We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases...
Year: 2021
Publications
Detection of involved margins in breast specimens with X-ray phase-contrast computed tomography
Institution: Department of Medical Physics and Biomedical Engineering, University College London
Keyword(s): X-ray phase contrast imaging, histology, involved margins
Summary: Margins of wide local excisions in breast conserving surgery are tested through histology, which can delay results by days and lead to second operations. Detection of margin inv...
Year: 2021
Publications
Exploring the potential of cycloidal computed tomography for advancing intraoperative specimen imaging
Institution: Department of Medical Physics and Biomedical Engineering, University College London
Keyword(s): cycloidal computed tomography, edge illumination, intraoperative specimen imaging, micro computed tomography, phase contrast, spatial resolution, structured illumination, X-ray imaging
Summary: A preliminary investigation into the use of cycloidal computed tomography for intraoperative specimen imaging is presented. Intraoperative imaging is applied in time-sensitive c...
Year: 2021
Publications
Exploring the potential of cycloidal computed tomography for advancing intraoperative specimen imaging
Institution: University College London
Keyword(s): -
Summary: A preliminary investigation into the use of cycloidal computed tomography for intraoperative specimen imaging is presented. Intraoperative imaging is applied in time-sensitive c...
Year: 2021
Publications
Gene-environment interactions relevant to estrogen and risk of breast cancer: Can gene-environment interactions be detected only among candidate snps from genome-wide association studies?
Institution: Seoul National University
Keyword(s): estrogen, gene-environment interaction
Summary: In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE...
Year: 2021
Publications
HER2-PI9 and HER2-I12: two novel and functionally active splice variants of the oncogene HER2 in breast cancer
Institution: Faculty of Medical Sciences, Newcastle University
Keyword(s): HER2, splice variants, trastuzumab, lapatinib, HER2-∆16, P100, herstatin
Summary: In this study, two novel alternative splice variants of HER2, named HER2-PI9 and HER2-I12, were identified in breast cancer cell lines and breast tumour tissues. Whilst HER2-P19...
Year: 2021
Publications
MicroRNA-495/TGF-β/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cells
Institution: Division of Cancer, Imperial College Faculty of Medicine
Keyword(s): FOXC1, galunisertib, metaplastic breast cancer, multidrug resistance, TGF-β, miR-495-3p
Summary: Triple-negative metaplastic breast carcinoma (MBC) poses a significant treatment challenge due to lack of targeted therapies and chemotherapy resistance. We isolated a novel MBC...
Year: 2021
