Publications
Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations
Institution: School of Medicine Medical Sciences and Nutrition, University of Aberdeen
Keyword(s): -
Summary: Half of all cancer patients receive radiotherapy, which makes a substantial contribution to their long-term disease control/cure. There are significant inter-patient differences...
Year: 2021
Publications
Role of IKK alpha in TNBC
Institution: University of Glasgow
Keyword(s): IHC
Summary: Breast cancer is the most frequently diagnosed cancer in women in the UK. Although several targeted therapies have been approved for patients with oestrogen-positive and HER2-po...
Year: 2021
Publications
SLC1A5 co-expression with TALDO1 associates with endocrine therapy failure in estrogen receptor-positive breast cancer
Institution: University of Nottingham Biodiscovery Institute
Keyword(s): estrogen receptor, SLC1A5, TALDO1, tamoxifen resistance
Summary: PURPOSE. Identification of effective biomarkers for the benefit of endocrine treatment and understanding the molecular pathways that contribute to the development of resistance...
Year: 2021
Publications
Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts
Institution: German Cancer Research Center (DKFZ)
Keyword(s): luminal breast cancer, cancer-associated fibroblasts, NRG1
Summary: HER3 is highly expressed in luminal breast cancer subtypes. Its activation by NRG1 promotes activation of AKT and ERK1/2, contributing to tumour progression and therapy resistan...
Year: 2021
Publications
The ITIM-containing receptor: Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) modulates immune response and confers poor prognosis in invasive breast carcinoma
Institution: School of Medicine, University of Nottingham
Keyword(s): LAIR-1, collagens, immune cell markers, prognosis
Summary: The leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) plays a role in immune response homeostasis, extracellular matrix remodelling and it is overexpressed in many hi...
Year: 2021
Publications
The biological and clinical significance of glutaminase in luminal breast cancer
Institution: University of Nottingham Biodiscovery Institute
Keyword(s): DCIS, IBC, glutaminase, prognosis
Summary: The glutamine metabolism has a key role in the regulation of uncontrolled tumour growth. This study aimed to evaluate the expression and prognostic significance of glutaminase i...
Year: 2021
Publications
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
Institution: Department of Pharmacology, University of Cambridge; Cancer Research UK Cambridge Cancer Centre
Keyword(s): BRCA1, triple negative breast cancer, loss of function, luminal progenitors
Summary: It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to ar...
Year: 2021
Publications
Tumor-infiltrating B lymphocyte profiling identifies IgG-biased, clonally expanded prognostic phenotypes in triple-negative breast cancer
Institution: King's College London
Keyword(s): B lymphocyte subsets, immunoglobulin expression, clonal features, triple negative breast cancer
Summary: In breast cancer, humoral immune responses may contribute to clinical outcomes, especially in more immunogenic subtypes. Here, we investigated B lymphocyte subsets, immunoglobul...
Year: 2021
Approved Project
Validation of markers for DCIS
Keyword(s): DCIS breast Invasive
Year: 2021
