Publications
Werner Syndrome Protein Expression in Breast Cancer
Institution: School of Medicine, University of Nottingham
Keyword(s): biomarker, helicase, Werner syndrome protein
Summary: INTRODUCTION. Werner protein (WRN) plays an important role in DNA repair, replication, transcription, and consequently genomic stability via its DNA-helicase and exonuclease act...
Year: 2021
Publications
A Mendelian randomization analysis of circulating lipid traits and breast cancer risk
Institution: Vanderbilt University School of Medicine
Keyword(s): lipids, cholesterol, genetics, Mendelian randomization, instrumental variable, epidemiology
Summary: BACKGROUND. Conventional epidemiologic studies have evaluated associations between circulating lipid levels and breast cancer risk, but results have been inconsistent. As Mendel...
Year: 2020
Publications
Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium
Institution: German Cancer Research Center (DKFZ); University Cancer Center Hamburg (UCCH)
Keyword(s): Gene-environment interaction, single nucleotide polymorphism, epidemiology, risk factors, Europeans
Summary: BACKGROUND. Previous gene-environment interaction studies of breast cancer risk have provided sparse evidence of interactions. Using the largest available dataset to date, we pe...
Year: 2020
Publications
CAFs and cancer cells co-Migration in 3D spheroid invasion assay
Institution: Barcelona Institute for Science and Technology (BIST)
Keyword(s): 3D spheroid invasion, cancer-associated fibroblasts, collective migration, epithelial cancer cells, leader/follower cells
Summary: In many solid tumors, collective cell invasion prevails over single-cell dissemination strategies. Collective modes of invasion often display specific front/rear cellular organi...
Year: 2020
Publications
Cancer burden is controlled by mural cell-β3-integrin regulated crosstalk with tumor cells
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): mural cell, β3-integrin, paracrine
Summary: Enhanced blood vessel (BV) formation is thought to drive tumor growth through elevated nutrient delivery. However, this observation has overlooked potential roles for mural cell...
Year: 2020
Publications
Characterisation of HER2 binding Affimer drug conjugates in 2D and 3D cell culture
Institution: University of Aberdeen
Keyword(s): -
Summary: -
Year: 2020
Publications
Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer
Institution: Barts Cancer Institute, Queen Mary University of London
Keyword(s): transcriptomics, proteomics, histologically normal tissue, reduction mammoplasty
Summary: Widespread mammographic screening programs and improved self-monitoring allow for breast cancer to be detected earlier than ever before. Breast-conserving surgery is a successfu...
Year: 2020
Publications
Co-expression effect of SLC7A5/SLC3A2 to predict response to endocrine therapy in oestrogen-receptor-positive breast cancer
Institution: University of Nottingham Biodiscovery Institute
Keyword(s): SLC3A2, SLC7A5, endocrine resistance, oestrogen receptor
Summary: The majority of breast cancers are oestrogen-receptor-positive (ER+) and are subject to endocrine therapy; however, an unpredictable subgroup of patients will develop resistance...
Year: 2020
Publications
Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers
Institution: Department of Biology, Georgia State University
Keyword(s): triple negative breast cancer, gene expression analysis, epidermal growth factor receptor, human epidermal growth factor receptor 3
Summary: Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (HER3) have been investigated as triple-negative breast cancer (TNBC) biomarkers. Reduced EG...
Year: 2020
