Publications
Cytoplasmic cyclin E Is an independent marker of aggressive tumor biology and breast cancer-specific mortality in women over 70 years of age
Institution: School of Medicine, University of Nottingham
Keyword(s): biomarker, cyclin E, older patients, prognosis, survival, tumor biology
Summary: Multi-cohort analysis demonstrated that cytoplasmic cyclin E expression in primary breast tumors predicts aggressive disease. However, compared to their younger counterparts, ol...
Year: 2020
Publications
Defining the role of MYBL2 in breast cancer progression
Institution: Institute of Cancer and Genomic Science, University of Birmingham
Keyword(s): MYBL2, metastasis, DNA-repair, EMT, stemness
Summary: The transcription factor MYBL2 (B-Myb) is upregulated in breast cancer and its associated with poor prognosis. MYBL2 overexpression promotes cell cycle progression, cell surviva...
Year: 2020
Publications
Derivation of a nuclear heterogeneity image index to grade DCIS
Institution: Department of Surgery, University of California
Keyword(s): heterogeneity, image analysis, nuclear morphology, pathology
Summary: Abnormalities in cell nuclear morphology are a hallmark of cancer. Histological assessment of cell nuclear morphology is frequently used by pathologists to grade ductal carcinom...
Year: 2020
Publications
Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival
Institution: School of Medicine, University of Nottingham; Faculty of Medicine, Menoufia University
Keyword(s): ECM remodelling, MMP9, prognosis
Summary: PURPOSE. MMP9 is a matricellular protein associated with extracellular matrix (ECM) remodelling, that promotes tumour progression, and modulates the activity of cell adhesion mo...
Year: 2020
Publications
Enhanced glutamine uptake influences composition of immune cell infiltrates in breast cancer
Institution: University of Nottingham
Keyword(s): IHC, glutamine, immune cell markers, progression
Summary: BACKGROUND. Cancer cells must alter their metabolism to support proliferation. Immune evasion also plays a role in supporting tumour progression. This study aimed to find whethe...
Year: 2020
Publications
Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions
Institution: Tumour Cell Biology Laboratory, Francis Crick Institute
Keyword(s): biomaterials - cells, cell migration, self-assembly, tissues
Summary: The isotropic or anisotropic organization of biological extracellular matrices has important consequences for tissue function. We study emergent anisotropy using fibroblasts tha...
Year: 2020
Publications
Glucocorticoid receptor expression predicts good Outcome in response to taxane-free, anthracycline-based therapy in triple negative breast cancer
Institution: School of Pharmacy, Queen's University Belfast
Keyword(s): transcriptomics, IHC, triple negative breast cancer, glucocorticoid receptor
Summary: Triple negative breast cancer (TNBC) is a poor outcome subset of breast cancers characterised by the lack of expression of ER α, PR, and HER2 amplification. It is a heterogeneou...
Year: 2020
Publications
IL6/STAT3 signaling hijacks estrogen receptor α enhancers to drive breast cancer metastasis
Institution: Cancer Research UK Cambridge Institute, University of Cambridge
Keyword(s): FOXA1, IL6, STAT3, estrogen receptor, metastasis, mouse intraductal xenograft model, pioneer factor
Summary: The cytokine interleukin-6 (IL6) and its downstream effector STAT3 constitute a key oncogenic pathway, which has been thought to be functionally connected to estrogen receptor α...
Year: 2020
Publications
Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer
Institution: Department of Oncology, University of Oxford
Keyword(s): triple negative breast cancer, glutamine, SLC38A2
Summary: BACKGROUND. Glutamine (Gln) is an abundant nutrient used by cancer cells. Breast cancers cells and particularly triple-receptor negative breast cancer (TNBC) are reported to be...
Year: 2020
