The Tissue Bank has helped drive cutting-edge research in early detection, enhanced diagnosis and therapeutics to help people live well with and beyond the disease.

To add to this catalogue, please complete our online form. Our return catalogue, records publications, links to molecular data generated, PhD projects and public engagement activities (e.g., talk and posters).

Project Title
BCNTB bioinformatics: the next evolutionary step in the bioinformatics of breast cancer tissue banking
BCCTBbp: the Breast Cancer Campaign Tissue Bank bioinformatics portal
Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects
Aurora Kinase A Is an independent predictor of invasive recurrence in breast ductal carcinoma in situ
Breast cancer: Investment biobanking--increased returns from tissue samples
Rare germline copy number variants (CNVs) and breast cancer risk
TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression
Detection of involved margins in breast specimens with X-ray phase-contrast computed tomography
Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway
A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer
Adding value to rare tissue samples donated to biobanks: characterisation of breast tissue and primary cell cultures obtained from a female-to-male transgender patient
Genomics England: Breast Cancer
Role of IKK alpha in TNBC
Dynamic biobanking for advancing breast cancer research
Characterization of the immune microenvironment in inflammatory breast cancer using multiplex immunofluorescence
The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples
Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock
Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study
Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival
Field cancerization in breast cancer
Incorporating progesterone receptor expression into the PREDICT breast prognostic model
Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion
Pin1 plays a key role in the response to treatment and clinical outcome in triple negative breast cancer
Cancer-associated fibroblasts induce an aggressive phenotypic shift in non-malignant breast epithelial cells via interleukin-8 and S100A8
MicroRNA-495/TGF-β/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cells
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
Tumor-infiltrating B lymphocyte profiling identifies IgG-biased, clonally expanded prognostic phenotypes in triple-negative breast cancer
PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer
CAFs and cancer cells co-Migration in 3D spheroid invasion assay
Clinicopathological significance of lipocalin 2 nuclear expression in invasive breast cancer
Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer
Enhanced glutamine uptake influences composition of immune cell infiltrates in breast cancer
Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts
Cytoplasmic cyclin E Is an independent marker of aggressive tumor biology and breast cancer-specific mortality in women over 70 years of age
Co-expression effect of SLC7A5/SLC3A2 to predict response to endocrine therapy in oestrogen-receptor-positive breast cancer
SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells
Werner Syndrome Protein Expression in Breast Cancer
The prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer
The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer
IL6/STAT3 signaling hijacks estrogen receptor α enhancers to drive breast cancer metastasis
Integrated analysis of key differentially expressed genes identifies DBN1 as a predictive marker of response to endocrine therapy in luminal breast cancer
HER2-PI9 and HER2-I12: two novel and functionally active splice variants of the oncogene HER2 in breast cancer
Visual histological assessment of morphological features reflects the underlying molecular profile in invasive breast cancer: a morphomolecular study
Volumetric high-resolution X-ray phase-contrast virtual histology of breast specimens with a compact laboratory system
SLC1A5 co-expression with TALDO1 associates with endocrine therapy failure in estrogen receptor-positive breast cancer
Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ
The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma
Derivation of a nuclear heterogeneity image index to grade DCIS
PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression
Discussion with French Biotech companies about potential collaborations
Predicting breast cancer recurrence using Natural Language Processing on imaging reports
Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers
The ITIM-containing receptor: Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) modulates immune response and confers poor prognosis in invasive breast carcinoma
Exploring the potential of cycloidal computed tomography for advancing intraoperative specimen imaging
XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib
The biological and clinical significance of glutaminase in luminal breast cancer
A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis
A human breast cell atlas mapping the homeostatic cellular shifts in the adult breast
ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation
Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel
Virtual alignment of pathology image series for multi-gigapixel whole slide images
Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival
Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research
Multiscale deep learning framework captures systemic immune features in lymph nodes predictive of triple negative breast cancer outcome in large-scale studies
High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer
Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry
Associations of a breast cancer polygenic risk score with tumor characteristics and survival
A proteolytic landscape: understanding the role of myoepithelial cells in early-stage breast cancer progression
Utility of stromal lymphocytes in diagnosis and predicting upgrade of B3 breast lesions from core biopsies
A biobank perspective on use of tissue samples donated by trial participants
Obituary - Margaret Wilcox
Capture Hi-C to identify regulatory variants and target genes influencing breast cancer risk
Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations
Exploring the potential of cycloidal computed tomography for advancing intraoperative specimen imaging
Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment
Gene-environment interactions relevant to estrogen and risk of breast cancer: Can gene-environment interactions be detected only among candidate snps from genome-wide association studies?
Breast cancer risk factors and survival by tumor subtype: Pooled analyses from the Breast Cancer Association Consortium
Combined associations of a polygenic risk score and classical risk factors with breast cancer risk. JNCI: Journal of the National Cancer Institute
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers
The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ
A Mendelian randomization analysis of circulating lipid traits and breast cancer risk
Cancer burden is controlled by mural cell-β3-integrin regulated crosstalk with tumor cells
The prognostic significance of immune microenvironment in breast ductal carcinoma in situ
Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium
Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions
CDC20 expression in oestrogen receptor positive breast cancer predicts poor prognosis and lack of response to endocrine therapy
Clinicopathological characteristics of Basal-like Breast Cancer (BLBC): a comparative study between Egyptian and British patients
Retinoid X receptor gamma (RXRG) is an independent prognostic biomarker in ER-positive invasive breast cancer
Geometric characteristics of collagen have independent prognostic significance in breast ductal carcinoma in situ: an image analysis study
Heparanase-dependent remodeling of initial lymphatic glycocalyx regulates tissue-fluid drainage during acute inflammation in vivo
ERCC1 Is a predictor of anthracycline resistance and taxane sensitivity in early stage or locally advanced breast cancers
SMAC, a computational system to link literature, biomedical and expression data
The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts
Atypical ductal hyperplasia is a multipotent precursor of breast carcinoma
Utility of ankyrin 3 as a prognostic marker in androgen-receptor-positive breast cancer.
Prognostic role of androgen receptor in triple negative breast cancer: a multi-institutional study
A key genomic subtype associated with lymphovascular invasion in invasive breast cancer
The prognostic significance of lysosomal protective protein (cathepsin A) in breast ductal carcinoma in situ
Oncogenic EP300 can be targeted with inhibitors of aldo-keto reductases
The clinical and biological significance of HER2 over-expression in breast ductal carcinoma in situ: a large study from a single institution
Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ
Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers
The combined expression of solute carriers is associated with a poor prognosis in highly proliferative ER+ breast cancer
Overexpression of the cancer stem cell marker CD133 confers a poor prognosis in invasive breast cancer
SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment
Expression of Lamin A/C in early-stage breast cancer and its prognostic value
Genome-wide association study of germline variants and breast cancer-specific mortality
Connexin 43 is an independent predictor of patient outcome in breast cancer patients
Glutamate dehydrogenase (GLUD1) expression in breast cancer
The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor
Kinesin family member-18A (KIF18A) is a predictive biomarker of poor benefit from endocrine therapy in early ER+ breast cancer
Investigation of hormone signalling and breast epithelial hierarchy in women at a high risk of cancer
Validation of a 3D perfused cell culture platform as a tool for humanised preclinical drug testing in breast cancer using established cell lines and patient-derived tissues
Prediction models for hormone receptor status in female breast cancer do not extend to males: further evidence of sex-based disparity in breast cancer
Implementing Fully Humanised Methods to Examine How the Endocrine Disrupting Chemical Bisphenol A Contributes to Breast Cancer Development
Characterisation of HER2 binding Affimer drug conjugates in 2D and 3D cell culture
Novel imaging modalities for the detection and characterisation of breast cancer
Collagen (XI) alpha-1 chain is an independent prognostic factor in breast ductal carcinoma in situ
Prolyl-4-hydroxylase Α subunit 2 (P4HA2) expression is a predictor of poor outcome in breast ductal carcinoma in situ (DCIS)
The significance of tumour microarchitectural features in breast cancer prognosis: a digital image analysis
Thioredoxin-interacting protein is an independent risk stratifier for breast ductal carcinoma in situ
Dual mechanisms of LYN kinase dysregulation drive aggressive behavior in breast cancer cells
Impact of breast cancer grade discordance on prediction of outcome
Heterogeneity of tumour‐infiltrating lymphocytes in breast cancer and its prognostic significance
Saccharomyces cerevisiae-like 1 (SEC14L1) is a prognostic factor in breast cancer associated with lymphovascular invasion
Clinicopathological and prognostic significance of Ras association and pleckstrin homology domains 1 (RAPH1) in breast cancer
Stanniocalcin 2 expression is associated with a favourable outcome in male breast cancer
Co-expression of nuclear P38 and hormone receptors is prognostic of good long-term clinical outcome in primary breast cancer and is linked to upregulation of DNA repair
An engineered human adipose/collagen model for in vitro breast cancer cell migration studies
Clinical and biological roles of Kelch-like family member 7 in breast cancer: a marker of poor prognosis
BQ323636.1, a novel splice variant to NCOR 2, as a predictor for tamoxifen-resistant breast cancer
Prognostic significance of tumor-infiltrating lymphocytes in ductal carcinoma in situ of the breast.
Breast cancer histologic grading using digital microscopy: concordance and outcome association
Immune infiltration in invasive lobular breast cancer
Characterising the adipose-inflammatory microenvironment in male breast cancer
The multifunctional solute carrier 3A2 (SLC3A2) confers a poor prognosis in the highly proliferative breast cancer subtypes
Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes
Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers
The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours
MYC regulation of glutamine-proline regulatory axis is key in luminal B breast cancer
Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells
Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer
Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
CIP2A expression predicts recurrences of tamoxifen-treated breast cancer
POPDC1 is suppressed in human breast cancer tissues and is negatively regulated by EGFR in breast cancer cell lines
Rho-GTPase activating-protein 18: a biomarker associated with good prognosis in invasive breast cancer
Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer
Ki67 expression in invasive breast cancer: the use of tissue microarrays compared with whole tissue section
How is Herstatin, a tumor suppressor splice variant of the oncogene HER2, regulated?
A case-matched gender comparison transcriptomic screen identifies eIF4E and eIF5 as potential prognostic markers in male breast cancer
Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers
Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function
Expression of CDK7, Cyclin H, and MAT1 is elevated in breast cancer and is prognostic in estrogen receptor-positive breast cancer
Management of breast cancer in an Asian man with post-traumatic stress disorder: a case report
An evaluation of matrix-containing and humanised matrix-free 3-dimensional cell culture systems for studying breast cancer
The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis
3-D tissue modelling and virtual pathology as new approaches to study ductal carcinoma in situ
Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo
Epigenetic mechanisms of breast cancer prevention by the Type II diabetes mellitus agent metformin
Epigenomic and genomic dissection of oestrogen receptor-positive breast cancer
Electrophysiological characterisation of ion channel activity in tumour slices
Exploring the roles of the Protein Kinase N family in breast cancer
Mechanostimulation of integrin αvβ6 and fibronectin in DCISmyoepithelial cells
The role of microRNAs in the fibroblasts of triple negative and basal-like breast cancer
Epigenomic profiling of oestrogen receptor-positive breast cancer
A comparative study of male versus female breast cancer identifies overexpression of eiF signalling pathways in male breast cancer providing opportunities for a therapeutic window
Breast Cancer Now Cell Culture Programme: a bespoke resource for the research community
A 3D in vitro model of the human breast duct: unravelling myoepithelial-luminal interactions in breast cancer
The sodium channel β1 subunit mediates outgrowth of neurite-like processes on breast cancer cells and promotes tumour growth and metastasis
Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer
Immunopeptidomic profiling of HLA-A2-positive triple negative breast cancer identifies potential immunotherapy target antigens
Glucocorticoid receptor expression predicts good Outcome in response to taxane-free, anthracycline-based therapy in triple negative breast cancer
Subcellular mRNA localization regulates ribosome biogenesis in migrating cells
Tumour promoting HER2 splice variant Δ16HER2: Regulation and implication in breast cancer
Reciprocal Interactions Between the Gut Microbiome and Mammary Tissue Mast Cells Promote Metastatic Dissemination of HR+ Breast Tumors
Defining the role of MYBL2 in breast cancer progression
Transcriptional implications of intragenic DNA methylation in the oestrogen receptor alpha gene in breast cancer cells and tissues